Leptin Levels and Weight Loss
What is Leptin?
Leptin is a hormone released from fat cells in tissue. Additionally, Leptin signals the hypothalamus, an area of the brain that tells the body to eat. Leptin does not affect food intake from meal to meal but, instead, acts to alter food intake and control energy expenditure over the long term. In contrast, Leptin has a more intense effect when we try to lose weight. Clearly, this stimulates a heavier appetite, cravings for carbs and sugars, and increased food intake. Also, this hormone helps maintain our average weight, and unfortunately for dieters, hard to lose those extra pounds! High leptin levels will not recognize that your body has plenty of fat stored, and you need to use this fat for energy. Your body keeps storing more and more body fat.
How is Leptin Controlled?
Due to the fact Leptin is produced by fat cells, the amount of Leptin released is wholly related to the amount of body fat we store, so the more fat we have, the more Leptin we will have stored in our blood. As we increase our fat mass, leptin levels rise. Needless to say, leptin levels decrease if we decrease our body’s fat mass over time. Basically, we must have a healthy body fat ratio to lean mass to control our Leptin levels naturally.
In other words, Leptin will tell the brain when to empty fat cells and utilize our fat for energy. Too much Leptin and body fat can trigger the brain to feel like you need to eat more. Plus, the brain does not see that there is enough “energy” or body fat that it can use. Hence, your body stores more and want to eat more!
Semaglutide and Exenatide act as a communication barrier to allow the brain to release fat for energy.