What Causes Leptin Resistance?
Leptin resistance usually develops over time due to three primary factors: (1) too little sleep, (2) too much stress and (3) too much of the wrong foods. Other factors that can contribute to its development include:
High insulin levels
High triglyceride levels
Too much sugar, especially high-fructose corn syrup
High stress (and resulting high cortisol levels)
Yo-yo dieting (alternating starvation with binge eating, especially)
Too little sun or time spent outdoors
Excessive snacking, especially late-night snacking and snacking on high-fructose, simple carbohydrate, overly processed foods
Exenatide also helps reduce insulin resistance. Insulin resistance is when cells in your body start resisting or ignoring the signal that insulin is trying to send out—which is to help glucose enter our cells from the bloodstream. Insulin is also a very important hormone involved in weight loss. High insulin levels make it almost impossible for your body to burn fat.
Insulin blocks an enzyme called hormone-sensitive lipase (HSL). This hormone is responsible for the mobilization of fatty acids from fat cell stores. If levels of insulin are high, it blocks this enzyme. Studies show that HSL is decreased in patients with type 2 diabetes mellitus, and this may be a consequence of elevated insulin levels. Excess insulin also has the added problem of promoting fat storage.
Exenatide helps sensitize the body to insulin levels and helps to lower blood glucose levels. It also helps reduce fasting insulin and glucose levels. Once insulin levels are stabilized to normal levels this may also improve other hormone imbalances (testosterone for example) which will naturally result in weight loss and a reduction in symptoms associated with those imbalances.
GLP-1 agonists like Exenatide help reduce insulin resistance and lower blood sugar. This then activates hormone-sensitive lipase and results in more fat burning activity over time.
Glucagon helps increase blood sugar levels while insulin lowers blood sugar levels. They are opposites. For hormone-sensitive lipase (fat burning enzyme) to be activated, insulin and glucagon (from glycogen stores) need to be at relatively low levels. High glucagon can also interfere with normal glucose control which in turn can alter how your body burns energy.
Exenatide and other GLP-1 agonists help reduce glucagon levels while simultaneously reducing insulin resistance. Both of these changes promote more normal blood glucose levels and help promote proper liver metabolism of glucose and help adipose tissue burn fat. Glucagon is just as important in the regulation of glucose levels in the body. Treating both insulin and glucagon leads to normal glucose levels and weight loss.
Exenatide helps naturally improve your metabolism, through its effects on leptin levels. Leptin feeds back to your hypothalamus and helps set your body set point – the number of calories your body burns which in terms alters your appetite.
Remember, our body is constantly trying to match the number of calories you burn to the number of calories that you consume.
This is an injection which ics completed twice per day. For more information, call your nearest MedShape clinic to get started!